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Vaccine Detail
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T. cruzi DNA vaccine encoding TSA-1 and Tc24 |
| Vaccine Information |
- Vaccine Name: T. cruzi DNA vaccine encoding TSA-1 and Tc24
- Target Pathogen: Trypanosoma cruzi
- Target Disease: Chagas disease
- Vaccine Ontology ID: VO_0004532
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Dogs
- Tc24 from Trypanosoma cruzi
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- TSA-1
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Dog Response
- Efficacy: Both preventive and therapeutic vaccination significantly reduced parasitemia, cardiac inflammation and cardiac parasite burden, and tended to reduce the development of cardiac arrhythmias (Quijano-Hernández et al., 2013).
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| References |
Quijano-Hernández et al., 2013: Quijano-Hernández IA, Castro-Barcena A, Vázquez-Chagoyán JC, Bolio-González ME, Ortega-López J, Dumonteil E. Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruzi. Vaccine. 2013; 31(18); 2246-2252. [PubMed: 23499599].
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