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Vaccine Detail
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Murine cytomegalovirus DNA vaccine pgM-pgN |
| Vaccine Information |
- Vaccine Name: Murine cytomegalovirus DNA vaccine pgM-pgN
- Target Pathogen: Murine Cytomegalovirus
- Vaccine Ontology ID: VO_0004526
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: gM and gN from murine cytomegalovirus strain Smith (Wang et al., 2013)
- gM
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- gN
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000158
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Co-immunization with pgM and pgN three times at a high dose was able to provide mice with full protection against a lethal SG-MCMV challenge with a 100% survival rate. The protection obtained with the gM-gN co-immunization was far greater than each antigen alone (Wang et al., 2013).
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| References |
Wang et al., 2013: Wang H, Yao Y, Huang C, Chen Q, Chen J, Chen Z. Immunization with cytomegalovirus envelope glycoprotein M and glycoprotein N DNA vaccines can provide mice with complete protection against a lethal murine cytomegalovirus challenge. Virologica Sinica. 2013; ; . [PubMed: 23715998].
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