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Vaccine Detail
PRRSV DNA vaccine pCI-ORF5/ORF6 |
Vaccine Information |
- Vaccine Name: PRRSV DNA vaccine pCI-ORF5/ORF6
- Target Pathogen: Porcine respiratory and reproductive syndrome virus
- Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
- Vaccine Ontology ID: VO_0004510
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse, pig
- GP5
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCl-neo expressed GP5 (encoded by ORF5) and M (encoded by ORF6) (Jiang et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000214
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Pig Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: All immunized piglets developed neutralizing antibodies at 10 weeks after primary immunization, whereas there was no detectable neutralizing antibodies in piglets immunized with pCI-ORF5. Neutralizing antibodies are considered to be important in protection against PRRSV (Jiang et al., 2006).
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References |
Jiang et al., 2006: Jiang Y, Xiao S, Fang L, Yu X, Song Y, Niu C, Chen H. DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity. Vaccine. 2006; 24(15); 2869-2879. [PubMed: 16446016].
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