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Vaccine Detail
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PRRSV DNA vaccine pIRESorf7/IL-2 |
| Vaccine Information |
- Vaccine Name: PRRSV DNA vaccine pIRESorf7/IL-2
- Target Pathogen: Porcine respiratory and reproductive syndrome virus
- Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
- Vaccine Ontology ID: VO_0004509
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Pig
- ORF7
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pIRES1neo expressed N, encoded by ORF7, which forms the nucleocapsid protein of the virus, and it is likely to contain virus-specific T cell epitopes (Xue et al., 2004).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pIRES1neo DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Pig Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: After immunization and viral challenge, one of three pigs immunized with pIRESorf7/IL-2 was protected from lung lesions that were present in other vaccinated and control animals (Xue et al., 2004).
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| References |
Xue et al., 2004: Xue Q, Zhao YG, Zhou YJ, Qiu HJ, Wang YF, Wu DL, Tian ZJ, Tong GZ. Immune responses of swine following DNA immunization with plasmids encoding porcine reproductive and respiratory syndrome virus ORFs 5 and 7, and porcine IL-2 and IFNgamma. Veterinary immunology and immunopathology. 2004; 102(3); 291-298. [PubMed: 15507312].
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