• Vaccine Name: PRRSV DNA vaccine pIRESorf5/IFNγ
• Target Pathogen: Porcine respiratory and reproductive syndrome virus
• Target Disease: Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease
• Vaccine Ontology ID: VO_0004507
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Pig
• ORF5 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pIRES1neo expressed GP5, encoded by ORF5, the major envelope protein of the virus harboring neutralizing epitopes (Xue et al., 2004).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005063
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: After immunization and viral challenge, two of three pigs immunized with pIRESorf5/IFNgamma were protected from lung lesions that were present in other vaccinated and control animals (Cho and Dee, 2006).