|
|
Vaccine Detail
|
Avian influenza virus DNA vaccine pCMV-HA |
| Vaccine Information |
- Vaccine Name: Avian influenza virus DNA vaccine pCMV-HA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004505
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- ha
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA 3.1 expressed H7 viral proteins from an Italian H7N1 LPAI virus (Le et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000158
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: After the homologous challenge, chickens of every vaccinated group displayed a significant decrease in cloacal shedding, whereas tracheal shedding was not significantly reduced in the protein/protein group (Le et al., 2007).
|
| References |
Le et al., 2007: Le Gall-Reculé G, Cherbonnel M, Pelotte N, Blanchard P, Morin Y, Jestin V. Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection. Avian diseases. 2007; 51(1 Suppl); 490-494. [PubMed: 17494616].
|
|
