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Vaccine Detail
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Avian influenza DNA vaccine pCMV-M |
| Vaccine Information |
- Vaccine Name: Avian influenza DNA vaccine pCMV-M
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004504
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- M1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA 3.1 expressed M1 viral proteins from an Italian H7N1 LPAI virus (Le et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000158
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: After the homologous challenge, chickens of every vaccinated group displayed a significant decrease in cloacal shedding, whereas tracheal shedding was not significantly reduced in the protein/protein group (Le et al., 2007).
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| References |
Le et al., 2007: Le Gall-Reculé G, Cherbonnel M, Pelotte N, Blanchard P, Morin Y, Jestin V. Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection. Avian diseases. 2007; 51(1 Suppl); 490-494. [PubMed: 17494616].
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