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Vaccine Detail
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Influenza virus DNA vaccine pCAGGoptiHA |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine pCAGGoptiHA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004502
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- HA from Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCAGGS expressed chicken biased codons based on the HA amino acid sequence of the highly pathogenic H5N1 virus A/goose/Guangdong/1/96 (GS/GD/96) (Jiang et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000099
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: All chickens receiving pCAGGoptiHA developed high levels of HI and NT antibodies at 3 weeks p.v., and were completely protected from lethal H5 virus challenge (Jiang et al., 2007).
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| References |
Jiang et al., 2007: Jiang Y, Yu K, Zhang H, Zhang P, Li C, Tian G, Li Y, Wang X, Ge J, Bu Z, Chen H. Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antiviral research. 2007; 75(3); 234-241. [PubMed: 17451817].
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