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Vaccine Detail
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Avian influenza virus DNA vaccine pH5HA |
| Vaccine Information |
- Vaccine Name: Avian influenza virus DNA vaccine pH5HA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004497
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse, ferret, macaque
- HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed H5 hemagglutinin (Laddy et al., 2008).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000019
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: After challenge, protection from morbidity and mortality was seen in mice and ferrets, with significant reductions in viral shedding and disease progression seen in vaccinated animals (Laddy et al., 2008).
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| References |
Laddy et al., 2008: Laddy DJ, Yan J, Kutzler M, Kobasa D, Kobinger GP, Khan AS, Greenhouse J, Sardesai NY, Draghia-Akli R, Weiner DB. Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PloS one. 2008; 3(6); e2517. [PubMed: 18575608].
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