• Vaccine Name: M. marinum pCMV-85A
• Target Pathogen: Mycobacterium marinum
• Vaccine Ontology ID: VO_0004496
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Fish
• fbpA gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA 3.1 expressed Mycobacterium marinum Ag85A gene (Pasnik and Smith, 2005).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000158
• Immunization Route: Intraperitoneal injection (i.p.)

Fish Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Fish receiving the DNA vaccine developed a protective response to a live M. marinum challenge 90 days post-inoculation, as demonstrated by increased survival of vaccinated fish over control fish and by reduced splenic bacterial counts in vaccinated fish (Pasnik and Smith, 2005).