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Vaccine Detail
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FeLV DNA vaccine gag/pol and env |
| Vaccine Information |
- Vaccine Name: FeLV DNA vaccine gag/pol and env
- Target Pathogen: Feline leukemia virus
- Target Disease: Feline leukemia virus infection
- Vaccine Ontology ID: VO_0004492
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Kitten
- env from FeLV-A/Glasgow
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pUSE1 expressed two separate pUSE12 series constructs, one expressing FeLV gag/pol genes and the other expressing the FeLV subgroup A env gene (Hanlon et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005051
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Cat Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The vaccine consisting of FeLV DNA with the IL-12 and IL-18 genes conferred significant immunity, protecting completely against transient and persistent viremia, and in five of six kittens protecting against latent infection (Hanlon et al., 2001).
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| References |
Hanlon et al., 2001: Hanlon L, Argyle D, Bain D, Nicolson L, Dunham S, Golder MC, McDonald M, McGillivray C, Jarrett O, Neil JC, Onions DE. Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors. Journal of virology. 2001; 75(18); 8424-8433. [PubMed: 11507187].
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