• Vaccine Name: Sindbis virus DNA vaccine encoding E2
• Target Pathogen: Sindbis virus
• Target Disease: Encephalitis
• Vaccine Ontology ID: VO_0004491
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• E2 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pCI-neo expressed the SV E2 gene with an upstream Kozak sequence and a downstream FLAG tag (Zanin et al., 2007).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000214
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: This vaccination strategy was immunogenic and provided partial protection against viral encephalitis in a murine model (Zanin et al., 2007).