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Vaccine Detail
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VEE virus DNA vaccine pSTU-TRDF encoding VEEV E3–E2–6K |
| Vaccine Information |
- Vaccine Name: VEE virus DNA vaccine pSTU-TRDF encoding VEEV E3–E2–6K
- Target Pathogen: VEE Virus
- Target Disease: Venezuelan equine encephalitis
- Vaccine Ontology ID: VO_0004490
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- C-E3-E2-E1-6K
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005072
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Particle-mediated epidermal delivery of a DNA vaccine encoding the E2 glycoprotein of VEEV can be boosted with a mucosally-delivered Ad-based vaccine encoding the same E2 glycoprotein, resulting in a significant increase in protection against airborne VEEV (Perkins et al., 2006).
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| References |
Perkins et al., 2006: Perkins SD, O'Brien LM, Phillpotts RJ. Boosting with an adenovirus-based vaccine improves protective efficacy against Venezuelan equine encephalitis virus following DNA vaccination. Vaccine. 2006; 24(17); 3440-3445. [PubMed: 16527377].
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