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Vaccine Detail
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Vaccinia virus DNA vaccine 4pox |
| Vaccine Information |
- Vaccine Name: Vaccinia virus DNA vaccine 4pox
- Target Pathogen: Vaccinia virus
- Vaccine Ontology ID: VO_0004485
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- A27L
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pWRG/TPA expressed VACV A27L (Hooper et al., 2007).
- Detailed Gene Information: Click Here.
- L1R
gene engineering:
- Type: DNA vaccine construction
- Description: This vaccine expressed L1R (Hooper et al., 2007).
- Detailed Gene Information: Click Here.
- A33R
gene engineering:
- Type: DNA vaccine construction
- Description: This vaccine expressed A33R (Hooper et al., 2007).
- Detailed Gene Information: Click Here.
- B5R
gene engineering:
- Type: DNA vaccine construction
- Description: This vaccine expressed B5R (Hooper et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000346
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Vaccinated mice were completely protected against a lethal (>10LD(50)) intranasal challenge with vaccinia virus strain IHD-J (Hooper et al., 2007).
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| References |
Hooper et al., 2007: Hooper JW, Golden JW, Ferro AM, King AD. Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge. Vaccine. 2007; 25(10); 1814-1823. [PubMed: 17240007].
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