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Vaccine Detail
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B. anthracis DNA vaccine pIMS-120 encoding PA |
| Vaccine Information |
- Vaccine Name: B. anthracis DNA vaccine pIMS-120 encoding PA
- Target Pathogen: Bacillus anthracis
- Target Disease: Anthrax
- Vaccine Ontology ID: VO_0004479
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rabbit
- pagA
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVAX1 expressed the mature 83 kDa full-length PA protein (without the 29 aminoacid prokaryotic secretory signal sequence) (Luxembourg et al., 2008).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000024
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rabbit Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Anthrax toxin neutralizing antibodies were also induced in rabbits immunized with electroporation with ED50 values comparable to those previously found to be protective in rabbits immunized with rPA (Luxembourg et al., 2008).
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| References |
Luxembourg et al., 2008: Luxembourg A, Hannaman D, Nolan E, Ellefsen B, Nakamura G, Chau L, Tellez O, Little S, Bernard R. Potentiation of an anthrax DNA vaccine with electroporation. Vaccine. 2008; 26(40); 5216-5222. [PubMed: 18462850].
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