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Vaccine Detail
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Dengue virus DNA vaccine pcTPANS1 encoding NS1 fused to the tissue plasminogen activator signal sequence |
| Vaccine Information |
- Vaccine Name: Dengue virus DNA vaccine pcTPANS1 encoding NS1 fused to the tissue plasminogen activator signal sequence
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Vaccine Ontology ID: VO_0004472
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- NS1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed the secretory signal sequence derived from human tissue plasminogen activator (t-PA) fused to the full length of the DENV-2 NS1 gene (Costa et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Vaccinated animals were challenged against DENV-2 in two murine models, based on intracerebral (i.c.) and intraperitoneal (i.p.) virus inoculations, and in both cases, pcTPANS1-immunized mice were protected (Costa et al., 2006).
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| References |
Costa et al., 2006: Costa SM, Paes MV, Barreto DF, Pinhão AT, Barth OM, Queiroz JL, Armôa GR, Freire MS, Alves AM. Protection against dengue type 2 virus induced in mice immunized with a DNA plasmid encoding the non-structural 1 (NS1) gene fused to the tissue plasminogen activator signal sequence. Vaccine. 2006; 24(2); 195-205. [PubMed: 16122850].
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