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Vaccine Detail
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S. mansoni DNA vaccine Sm-p80-pcDNA3 encoding the large subunit of S. mansoni calpain |
| Vaccine Information |
- Vaccine Name: S. mansoni DNA vaccine Sm-p80-pcDNA3 encoding the large subunit of S. mansoni calpain
- Target Pathogen: Schistosoma mansoni
- Target Disease: Schistosomiasis
- Vaccine Ontology ID: VO_0004464
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- calpain
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice immunized with Sm-p80-pcDNA3 showed statistically significant 39% reduction in worm burden when compared with mice which received only pcDNA3. Similarly, mice immunized with Sm-p80-pcDNA3 and co-injected with pORF-mIL-2 exhibited 57% reduction (P≤0.0001) in the number of parasites when compared with the group of mice receiving only pcDNA3 and pORF-mIL-2. Also, when mice were primed with Sm-p80-pcDNA3 in the presence of pORF-mIL-12, they contained 45% less number of parasites (P≤0.0001) compared to the group of mice which were immunized with pcDNA3 alone (Siddiqui et al., 2003).
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| References |
Siddiqui et al., 2003: Siddiqui AA, Phillips T, Charest H, Podesta RB, Quinlin ML, Pinkston JR, Lloyd JD, Pompa J, Villalovos RM, Paz M. Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation. Vaccine. 2003; 21(21-22); 2882-2889. [PubMed: 12798631].
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