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Vaccine Detail
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S. mansoni DNA vaccine pcDNA/CTSOD encoding SOD |
| Vaccine Information |
- Vaccine Name: S. mansoni DNA vaccine pcDNA/CTSOD encoding SOD
- Target Pathogen: Schistosoma mansoni
- Target Disease: Schistosomiasis
- Vaccine Ontology ID: VO_0004462
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- SOD
gene engineering:
- Type: DNA vaccine construction
- Description: Vector cDNAI/Amp (in vitrogen) expressed Cu/Zn superoxide dismutase, SOD (Shalaby et al., 2003).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000130
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: CT-SOD showed the highest level of protection out of all vaccines tested (54%). Two immunizations resulted in significant reduction of worm burden compared to control groups (Shalaby et al., 2003).
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| References |
Shalaby et al., 2003: Shalaby KA, Yin L, Thakur A, Christen L, Niles EG, LoVerde PT. Protection against Schistosoma mansoni utilizing DNA vaccination with genes encoding Cu/Zn cytosolic superoxide dismutase, signal peptide-containing superoxide dismutase and glutathione peroxidase enzymes. Vaccine. 2003; 22(1); 130-136. [PubMed: 14604580].
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