• Vaccine Name: ProQuad
• Target Pathogen: Rubella virus
• Target Disease: Rubella
• Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live
• Tradename: ProQuad
• Manufacturer: Merck & Co, Inc.
• Vaccine Ontology ID: VO_0000091
• CDC CVX code: 94
• Type: Live, attenuated vaccine
• Status: Licensed
• Location Licensed: USA (License #0002)
• Host Species for Licensed Use: Human
• Preparation: propagated in WI-38 human diploid lung fibroblasts (FDA: Proquad).
• Immunization Route: Intramuscular injection (i.m.)
• Storage: 2° to 8°C (36° to 46°F) or colder.
• Approved Age for Licensed Use: 12 months to 12 years old
• Contraindication: Vaccine should not be administered to anyone with a known history of anaphylactic reactions to neomycin, or to anyone with a history of hypersensitivity to gelatin or any other component of the vaccine (FDA: Proquad).
• Description: ProQuad is a sterile lyophilized preparation of (1) the components of M-M-R*II (Measles, Mumps and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; Mumps Virus Vaccine Live, the Jeryl Lynn™ (B level) strain of mumps virus propagated in chick embryo cell culture; Rubella Virus Vaccine Live, the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts; and (2) Varicella Virus Vaccine Live (Oka/Merck) refrigerator-stable formulation, the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells (FDA: Proquad).

Human Response

• Immune Response: According to clinical trials, there were high levels of antibodies in 99.6% of those vaccinated after a single dose of Proquad (FDA: Proquad).
• Side Effects: Side effects of vaccination include: injection site reactions, fever, irritability and diarrhea.