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Vaccine Detail
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Chinese S. japonicum DNA vaccine pVAX/SjFABP encoding FABP |
| Vaccine Information |
- Vaccine Name: Chinese S. japonicum DNA vaccine pVAX/SjFABP encoding FABP
- Target Pathogen: Schistosoma japonicum
- Target Disease: Schistosomiasis
- Vaccine Ontology ID: VO_0004457
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FABP
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pVAX1 expressed Schistosoma japonicum 14 kDa fatty acid binding protein (SjFABP) (Wei et al., 2009).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000024
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The mice inoculated intramuscularly with pVAX/SjFABP showed significant worm reduction rate of 22.94% (P < 0.05) and egg reduction rate of 30.23% when compared with the pVAX1 control group. The addition of the pVAX/mIL-18 plasmids dramatically enhanced protection with worm reduction rate of 36.92% and egg reduction rate of 43.23% (P < 0.05), compared to the pVAX/SjFABP group (Wei et al., 2009).
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| References |
Wei et al., 2009: Wei F, Liu Q, Zhai Y, Fu Z, Liu W, Shang L, Men J, Gao S, Lian H, Jin H, Chen C, Lin J, Shi Y, Xia Z, Zhu XQ. IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine. Acta tropica. 2009; 111(3); 284-288. [PubMed: 19467215].
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