• Vaccine Name: Chinese S. japonicum DNA vaccine pCMV-Sjc97 encoding paramyosin
• Target Pathogen: Schistosoma japonicum
• Target Disease: Schistosomiasis
• Vaccine Ontology ID: VO_0004456
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Paramyosin gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA vector/Amp expressed the full-length cDNA encoding paramyosin of Chinese S. japonicum (Sjc97) (Zhou et al., 2000).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000130
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: In three separate experiments, pCMV-Sjc97, inoculated intramuscularly three times at doses of 100 or 200 μg per C57BL/6 mouse, was found to provide significant worm reduction rates. In addition, there was a substantial reduction in the number of eggs present in the livers and spleens of the pCMV-Sjc97 immunized group when compared with the pCMV blank vector control groups. Therefore, preliminary results suggest pCMV-Sjc97 can confer protective immunity in C57BL/6 mice (Zhou et al., 2000).