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Vaccine Detail
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T. gondii DNA vaccine T.g.HSP70 |
| Vaccine Information |
- Vaccine Name: T. gondii DNA vaccine T.g.HSP70
- Target Pathogen: Toxoplasma gondii
- Target Disease: Toxoplasmosis
- Vaccine Ontology ID: VO_0004455
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- hsp70
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000356
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The T.g.HSP70 gene vaccination induced protective immunity against T.g.HSP70-induced anaphylactic reaction not only at the acute phase but also at acute exacerbation of the chronic phase of infection, although the protective effect was partial (Kikumura et al., 2010).
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| References |
Kikumura et al., 2010: Kikumura A, Fang H, Mun HS, Uemura N, Makino M, Sayama Y, Norose K, Aosai F. Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene. Parasitology international. 2010; 59(2); 105-111. [PubMed: 20346412].
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