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Vaccine Detail
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T. gondii DNA vaccine pVR1020-GRA1 |
| Vaccine Information |
- Vaccine Name: T. gondii DNA vaccine pVR1020-GRA1
- Target Pathogen: Toxoplasma gondii
- Target Disease: Toxoplasmosis
- Vaccine Ontology ID: VO_0004454
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- GRA1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector VR1020 expressed T. gondii excreted-secreted dense granule proteins GRA1 (Scorza et al., 2003).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pVR1020 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: All control pVR1020-vaccinated mice succumbed to infection after challenge, while 75% of the mice vaccinated with pVR1020-GRA1 were protected against infection with strain IPB-G. In the second experiment, all mice vaccinated with GRA1 DNA survived, while 75% of the mice vaccinated with control DNA succumbed to infection (P < 0.05) (Scorza et al., 2003).
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| References |
Scorza et al., 2003: Scorza T, D'Souza S, Laloup M, Dewit J, De Braekeleer J, Verschueren H, Vercammen M, Huygen K, Jongert E. A GRA1 DNA vaccine primes cytolytic CD8(+) T cells to control acute Toxoplasma gondii infection. Infection and immunity. 2003; 71(1); 309-316. [PubMed: 12496180].
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