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Vaccine Detail
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Prostate cancer DNA vaccine pmPSCA encoding PSCA |
| Vaccine Information |
- Vaccine Name: Prostate cancer DNA vaccine pmPSCA encoding PSCA
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004452
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Prostate stem cell antigen
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pIRES2 DsRed2 expressed murine prostate stem cell antigen (PSCA) (Ahmad et al., 2009).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pIRES2 DsRed2 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: These experiments demonstrated 37% relative risk reduction of tumor development in the pmPSCA group, but importantly vaccinated tumor bearing mice also had significantly less tumor burden than the control groups. Tumor growth kinetics indicated slower tumor growth in the pmPSCA treated group (versus empty vector P = 0.04, versus untreated P = 0.01). These results demonstrated that the pmPSCA could provide either complete protection or result in containment of the disease (Ahmad et al., 2009).
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| References |
Ahmad et al., 2009: Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Molecular therapy : the journal of the American Society of Gene Therapy. 2009; 17(6); 1101-1108. [PubMed: 19337234].
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