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Vaccine Detail
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Prostate cancer DNA vaccine encoding PSCA |
| Vaccine Information |
- Vaccine Name: Prostate cancer DNA vaccine encoding PSCA
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004451
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Prostate stem cell antigen
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed prostate stem cell antigen (PSCA) (Garcia-Hernandez et al., 2008).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Eight-week-old TRAMP mice displaying prostate intraepithelial neoplasia were vaccinated with a heterologous prime/boost strategy consisting of gene gun-delivered PSCA-cDNA followed by Venezuelan equine encephalitis virus replicons encoding PSCA. PSCA-vaccinated TRAMP mice had a 90% survival rate at 12 months of age. In contrast, all control mice had succumbed to prostate cancer or had heavy tumor loads (Garcia-Hernandez et al., 2008).
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| References |
Garcia-Hernandez et al., 2008: Garcia-Hernandez Mde L, Gray A, Hubby B, Klinger OJ, Kast WM. Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity. Cancer research. 2008; 68(3); 861-869. [PubMed: 18245488].
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