• Vaccine Name: Neuroblastoma DNA vaccine HuDsec
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004444
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• HuD gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA 3.1 expressed Hu proteins which are the human homologues of the Drosophila protein elav, including HuD (Carpentier et al., 1998).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000132
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Immunized animals were challenged by s.c. implantation of a neuroblastoma cell line that constitutively expresses HuD. When compared with controls, mice immunized with the secreted HuD showed significant tumor growth inhibition (51% reduction volume; P = 0.0012), and 14% of them had complete tumor rejection (Carpentier et al., 1998).