|
|
Vaccine Detail
|
Melanoma DNA vaccine hTRP2 encoding TRP-2 |
| Vaccine Information |
- Vaccine Name: Melanoma DNA vaccine hTRP2 encoding TRP-2
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004442
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: TRP-2
- TRP-2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCR3 expressed human-tyrosinase-related protein-2 (hTRP2) (Hawkins et al., 2002).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000232
- Immunization Route: Gene gun
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Immunization of mice with xenogeneic hTRP2 DNA results in tumor immunity against intravenous tumor challenge with a syngeneic mouse B16F10LM3 melanoma known to express TRP2. All mice (100%) immunized with hTRP2 were protected from challenge with B16F10LM3 melanoma while all control PCR3 vector immunized mice (100%) developed tumors (P < 0.0001). However, growth of established tumors was not inhibited (Hawkins et al., 2002).
|
| References |
Hawkins et al., 2002: Hawkins WG, Gold JS, Blachere NE, Bowne WB, Hoos A, Lewis JJ, Houghton AN. Xenogeneic DNA immunization in melanoma models for minimal residual disease. The Journal of surgical research. 2002; 102(2); 137-143. [PubMed: 11796010].
|
|
