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Vaccine Detail
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Melanoma recombinant vector vaccine rVVmTRP-1 encoding TRP-1 |
| Vaccine Information |
- Vaccine Name: Melanoma recombinant vector vaccine rVVmTRP-1 encoding TRP-1
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004441
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- TRP-1
gene engineering:
- Type: Recombinant vector construction
- Description: Vector pSC65 and rVV expressed tyrosinase-related protein TRP-1 (Overwijk et al., 1999).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Challenge of vaccinated β2m knockout mice with B16 melanoma revealed robust protection against melanoma growth (Overwijk et al., 1999).
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| References |
Overwijk et al., 1999: Overwijk WW, Lee DS, Surman DR, Irvine KR, Touloukian CE, Chan CC, Carroll MW, Moss B, Rosenberg SA, Restifo NP. Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 1999; 96(6); 2982-2987. [PubMed: 10077623].
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