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Vaccine Detail

Melanoma DNA vaccine VR1012/mPmel17
Vaccine Information
  • Vaccine Name: Melanoma DNA vaccine VR1012/mPmel17
  • Target Pathogen: Cancer
  • Target Disease: Cancer
  • Vaccine Ontology ID: VO_0004439
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • Pmel17 gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000334
  • Immunization Route: Intradermal injection (i.d.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: More than half of the animals that had received VR1012/mPmel17 pDNA were protected completely (eight of 15 = 53.3%) against the highly tumorigenic dose of 1X105 M3-7 cells. None of these protected animals developed a tumor at a later time point during an entire observation period of 4 months. By contrast, control animals that had been injected with vector VR1012 pDNA alone consistently failed to reject Pmel17high M3-7 melanoma cells (Wagner et al., 2000).
References
Wagner et al., 2000: Wagner SN, Wagner C, Lührs P, Weimann TK, Kutil R, Goos M, Stingl G, Schneeberger A. Intracutaneous genetic immunization with autologous melanoma-associated antigen Pmel17/gp100 induces T cell-mediated tumor protection in vivo. The Journal of investigative dermatology. 2000; 115(6); 1082-1087. [PubMed: 11121145].