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Vaccine Detail
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Melanoma DNA vaccine hugp100 encoding gp100 |
| Vaccine Information |
- Vaccine Name: Melanoma DNA vaccine hugp100 encoding gp100
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004438
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- gp100 (PMEL)
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pWRG1644 expressed the human melanoma-associated antigen, gp100 (Rakhmilevich et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000346
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Particle-mediated delivery of the gp100 plasmid resulted in substantial protection against B16-gp100 tumors, with 40% of the mice remaining tumor free for at least 2 months. Importantly, co-delivery of mGM-CSF DNA with hugp100 DNA resulted in complete tumor protection in all five vaccinated mice (Rakhmilevich et al., 2001).
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| References |
Rakhmilevich et al., 2001: Rakhmilevich AL, Imboden M, Hao Z, Macklin MD, Roberts T, Wright KM, Albertini MR, Yang NS, Sondel PM. Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001; 7(4); 952-961. [PubMed: 11309346].
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