|
|
Vaccine Detail
|
Colorectal cancer DNA vaccine pCEA/HBsAg encoding carcinoembryonic antigen and hepatitis B surface antigen |
| Vaccine Information |
- Vaccine Name: Colorectal cancer DNA vaccine pCEA/HBsAg encoding carcinoembryonic antigen and hepatitis B surface antigen
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004428
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Human
- S
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed the small and middle proteins of the Hepatitis B surface antigen (Conry et al., 2002).
- Detailed Gene Information: Click Here.
- CEACAM5 (CEA)
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed the carcinoembryonic antigen (Conry et al., 2002).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Human Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Repetitive dosing of pCEA/HBsAg induced HBsAg antibodies in 6 of 8 patients, and 4 of these patients achieved protective antibody levels (>10 mIU/ml) (Conry et al., 2002).
|
| References |
Conry et al., 2002: Conry RM, Curiel DT, Strong TV, Moore SE, Allen KO, Barlow DL, Shaw DR, LoBuglio AF. Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002; 8(9); 2782-2787. [PubMed: 12231517].
|
|
