• Vaccine Name: B-cell lymphoma DNA vaccine VCL-1642.XXX encoding a chimeric immunoglobulin molecule onsisting of tumor-specific variable (Id) regions
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004427
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Human
• Antigen: Immunoglobulin
• Immunoglobulin gene engineering:
  • Type: DNA vaccine construction
  • Description: The DNA encoded a chimeric immunoglobulin molecule containing variable heavy and light chain immunoglobulin sequences derived from each patient’s tumor (Timmerman et al., 2002).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005009
• Preparation: The vaccine is made of DNA encoded a chimeric immunoglobulin molecule containing variable heavy and light chain immunoglobulin sequences derived from each patient’s tumor, linked to the IgG2a and κ mouse immunoglobulin (MsIg) heavy- and light-chain constant regions chains, respectively (Timmerman et al., 2002). DNA used could also encode an ld/GM-CSF (Syrengelas et al., 1996).
• Immunization Route: Intramuscular injection (i.m.)
• Description: This vaccine has been used in clinical trials involving B-cell lymphoma. (Syrengelas et al., 1996)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Immunization with 10–100 μg induced specific anti-ld antibody responses and protected mice against tumor challenge (Timmerman et al., 2002; Syrengelas et al., 1996).