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Vaccine Detail
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VEE virus recombinant vector vaccine RAd/VEEV#2 |
| Vaccine Information |
- Vaccine Name: VEE virus recombinant vector vaccine RAd/VEEV#2
- Target Pathogen: VEE Virus
- Target Disease: Venezuelan equine encephalitis
- Vaccine Ontology ID: VO_0004423
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: E3-E2-6K from VEEV TC-83 with two mutations in the major neutralisation site of E. (Phillpotts et al., 2005)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Intranasal immunisation of mice with this recombinant virus produced a vigorous antibody response, with local IgA also detectable in respiratory secretions accompanied by highly significant protection against airborne VEEV challenge (Phillpotts et al., 2005).
- Efficacy: This vaccine provided protection against low dose challenge (73 LD50); 4 out of 6 challenged mice survived (Phillpotts et al., 2005).
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| References |
Phillpotts et al., 2005: Phillpotts RJ, O'brien L, Appleton RE, Carr S, Bennett A. Intranasal immunisation with defective adenovirus serotype 5 expressing the Venezuelan equine encephalitis virus E2 glycoprotein protects against airborne challenge with virulent virus. Vaccine. 2005 Feb 18; 23(13); 1615-23. [PubMed: 15694514].
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