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Vaccine Detail
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H. rhabdovirus DNA vaccine pHRV-G encoding HIRRV and VHSV G proteins |
| Vaccine Information |
- Vaccine Name: H. rhabdovirus DNA vaccine pHRV-G encoding HIRRV and VHSV G proteins
- Target Pathogen: Hirame rhabdovirus
- Vaccine Ontology ID: VO_0004419
- Type: DNA vaccine
- Status: Research
- G glycoprotein
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000214
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Fish Response
- Immune Response: A type I IFN system was stimulated by vaccination with pHRV-G in the Japanese flounder, which contributes not only to innate immunity but also to acquired immunity. In addition, type I IFN plays a role in Th1 polarization of the immune response induced by DNA vaccination (Yasuike et al., 2007).
- Efficacy: Fourteen days after the HIRRV challenge, cumulative mortalities of the fish injected with pHRV-G was 13%, as compared to the cumulative mortalities of the control group which was at 98%. This confirmed previous protection studies which demonstrated the efficacy of this vaccine (Yasuike et al., 2007).
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| References |
Yasuike et al., 2007: Yasuike M, Kondo H, Hirono I, Aoki T. Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Fish & shellfish immunology. 2007; 23(3); 531-541. [PubMed: 17449275].
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