• Vaccine Name: Herpes simplex virus DNA vaccine pSIN-gB encoding gB
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004411
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• UL27 from Herpes simplex virus type 1 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector Sindbis virus-based (pSIN vectors) expressed glycoprotein B of herpes simplex virus type 1 (Hariharan et al., 1998).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000317
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: A single intramuscular immunization of BALB/c mice with pSIN vectors expressing the glycoprotein B of herpes simplex virus type 1 induced a broad spectrum of immune responses, including virus-specific antibodies, cytotoxic T cells, and protection from lethal virus challenge in two different murine models (Hariharan et al., 1998).
• Efficacy: 100% of the mice surviving the lethal i.p. McKrae challenge, demonstrating complete protection. None of the mice immunized with 100-μg doses of either negative control plasmid (pCI-HBVe or pSIN1.5-HBVe) survived (Hariharan et al., 1998).