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Vaccine Detail
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Autoimmune diabetes DNA vaccine pND2-SGAD55 |
| Vaccine Information |
- Vaccine Name: Autoimmune diabetes DNA vaccine pND2-SGAD55
- Target Pathogen: Diabetes
- Target Disease: Diabetes
- Vaccine Ontology ID: VO_0004403
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- GAD65
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pND2 expressed sgad55, a modified gad65 cDNA encoding a secreted truncated form of human GAD65 (Filippova et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pND2 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: A Kaplan- Meier plot of diabetes onset, together with statistical analysis, indicated that mice that received injection of pND2- SGAD55 plasmid DNA had a significant reduction in diabetes compared with untreated control animals (P = 0.05; log-rank test). In contrast, mice that received pND2-GAD65 did not show significant diabetes reduction compared with the same controls (P = 0.37; log-rank test) (Filippova et al., 2001).
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| References |
Filippova et al., 2001: Filippova M, Liu J, Escher A. Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA and cell biology. 2001; 20(3); 175-181. [PubMed: 11313020].
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