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Vaccine Detail
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B. melitensis DNA vaccine pCI-Omp31 |
| Vaccine Information |
- Vaccine Name: B. melitensis DNA vaccine pCI-Omp31
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0004394
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- omp31
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCI expressed Omp31 (hemin-binding protein) (Cassataro et al., 2005).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000214
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: The Omp31 DNA vaccine induces cytotoxic responses that have the potential to contribute to protection against Brucella infection. The protective response could be related to the induction of CD8(+) T cells that eliminate Brucella-infected cells via the perforin pathway (Cassataro et al., 2005).
- Efficacy: Mice given pCIOmp31 exhibited a significant degree of protection against B. melitensis and B. ovis (P < 0.001) compared with controls receiving PBS. This was determined by comparing the levels of infection in the spleen (CFU) (Cassataro et al., 2005).
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| References |
Cassataro et al., 2005: Cassataro J, Velikovsky CA, de la Barrera S, Estein SM, Bruno L, Bowden R, Pasquevich KA, Fossati CA, Giambartolomei GH. A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response. Infection and immunity. 2005 Oct; 73(10); 6537-46. [PubMed: 16177328].
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