• Vaccine Name: Marburg virus DNA vaccine MARV GP encoding GP
• Target Pathogen: Marburg Virus
• Target Disease: Hemorrhagic fever
• Vaccine Ontology ID: VO_0004387
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, rabbit, guinea pig
• GP from Marburg virus Ravn gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pWRG7077 expressed MARV Musoke GP in challenge study with macaques (Riemenschneider et al., 2003).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000346
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: All of the MARV GP DNA-vaccinated guinea pigs developed antibodies to MARV (Riemenschneider et al., 2003).
• Efficacy: In both studies (two different strains - Musoke and Ravn), two of three GP DNA-vaccinated monkeys were aviremic on the days assayed, and survived challenge, while one monkey in each study developed viremia levels similar to those of control monkeys and died. These results indicate that DNA vaccination alone is able to offer immunity to nonhuman primates, but suggest that the protective effect is near the threshold of vaccine efficacy (Riemenschneider et al., 2003).