• Vaccine Name: Ebola virus DNA vaccine DNA/rAd5 encoding ZEBOV and SEBOV antigens
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Vaccine Ontology ID: VO_0004385
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Macaque
• GP from Sudan ebolavirus gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• GP from Zaire ebolavirus gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005050
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Vaccination Protocol: Four cynomolgus macaques were injected at 4–6 week intervals with GP(Z) and GP(S/G) DNA, followed by a rest period, and boosted after one year with rAd5 vectors containing the EBOV matched insert (Hensley et al., 2010).
• Vaccine Immune Response Type: VO_0000286
• Immune Response: DNA/rAd prime-boost EBOV immunization generated antigen-specific CD4+ T cell immunity against proteins expressed by the vaccine insert. The magnitude of antigen-specific CD4+ T cells was uniform across the four immunized macaques (Hensley et al., 2010).
• Efficacy: DNA/rAd5 immunization of cynomolgus macaques protects against infection when animals are challenged with a virus species homologous to the vaccine inserts (Hensley et al., 2010).