• Vaccine Name: Ebola virus recombinant vector vaccine Ad-CMVZGP encoding the glycoprotein
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Vaccine Ontology ID: VO_0004383
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• GP from Zaire ebolavirus gene engineering:
  • Type: Recombinant vector construction
  • Description: Vector Human adenovirus serotype 5 (Ad) expressed the Zaire ebolavirus (ZEBOV) envelope glycoprotein (Richardson et al., 2009).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Vaccination following viral challenge produced enhanced T and B cell immune responses with a low dose of Ad-CAGoptZGP. The frequency of IFN-γ+CD8 T cells with Ad-CMVZGP at 1×10^7 IFU/mouse was at 1.6±0.4%, on average (Richardson et al., 2009).
• Efficacy: Protection following Zaire ebola virus challenge was complete in mice vaccinated with Ad-CMVZGP at 1×10^6 and 1×10^7 IFU/mouse but was only partially protective at 1×10^5 IFU/mouse (Richardson et al., 2009).