• Vaccine Name: Ebola virus recombinant adenovirus vaccine AdC7-ZGP encoding GP
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Vaccine Ontology ID: VO_0004382
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• GP from Zaire ebolavirus gene engineering:
  • Type: Recombinant vector construction
  • Description: Vector adenoviral (ADV) expressed the Ebola envelope glycoprotein (GP) (Kobinger et al., 2006).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001055
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: AdC7 vaccine stimulated robust T and B cell responses to ZEBOV in naïve mice (Kobinger et al., 2006).
• Efficacy: Mice were immunized with a single dose of 5 × 10^10 particles per animal as performed previously and vaccinated animals were challenged with 200 LD50 of the mouse-adapted strain of ZEBOV 21 days later. All control mice (vehicle and AdHu5-LacZ) died between days 5 and 9 post-challenge. In contrast, all mice vaccinated with AdC7-ZGP survived the challenge with mouse-adapted ZEBOV. Weight loss was observed only from control groups (vehicle and AdHu5-LacZ). Complete protection following vaccination with 5 × 10^10 particles of AdC7-ZGP was demonstrated with challenge doses of ZEBOV up to 200,000 LD50, which was the highest dose tested (Kobinger et al., 2006).