• Vaccine Name: Ebola virus DNA vaccine EBOV GP
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Vaccine Ontology ID: VO_0004036
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, rabbit, guinea pig
• GP from Zaire ebolavirus gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pWRG7077 expressed Ebola virus GP gene sequences (Riemenschneider et al., 2003).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000346
• Immunization Route: Gene gun

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The mice had low neutralizing antibody responses, yet were protected from challenge. This, as indicated by earlier studies, may be due to gene gun vaccination, which generally elicits a TH2-type response in BALB/c mice (Riemenschneider et al., 2003).
• Efficacy: Two vaccinations with the EBOV GP DNA elicited consistently high antibody responses and conferred complete protection from EBOV challenge (Riemenschneider et al., 2003).