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Vaccine Detail

Lassa fever virus recombinant vector vaccine YFV17D/LASV-GPC encoding the glycoprotein precursor
Vaccine Information
  • Vaccine Name: Lassa fever virus recombinant vector vaccine YFV17D/LASV-GPC encoding the glycoprotein precursor
  • Target Pathogen: Lassa Fever Virus
  • Target Disease: Lassa fever
  • Vaccine Ontology ID: VO_0004380
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Guinea pig
  • GPC gene engineering:
    • Type: Recombinant vector construction
    • Description: Vector Yellow Fever Vaccine 17D (YFV17D) expressed the Lassa virus glycoprotein precursor (LASV-GPC) (Bredenbeek et al., 2006).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Guinea pig Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: The YFV17D/LAS-GPC vaccination elicited humoral immune responses against YFV17D and LASV antigens. Neutralizing antibodies play the major role in protection against yellow fever (Bredenbeek et al., 2006).
  • Efficacy: A single subcutaneous injection of the recombinant vaccine protected 13 guinea pigs against fatal Lassa Fever (Bredenbeek et al., 2006).
References
Bredenbeek et al., 2006: Bredenbeek PJ, Molenkamp R, Spaan WJ, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov I, Patterson J, Carrion R, Ticer A, Brasky K, Lukashevich IS. A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins. Virology. 2006 Feb 20; 345(2); 299-304. [PubMed: 16412488].