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Vaccine Detail
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Lassa fever virus recombinant vector vaccine YFV17D/LASV-GPC encoding the glycoprotein precursor |
| Vaccine Information |
- Vaccine Name: Lassa fever virus recombinant vector vaccine YFV17D/LASV-GPC encoding the glycoprotein precursor
- Target Pathogen: Lassa Fever Virus
- Target Disease: Lassa fever
- Vaccine Ontology ID: VO_0004380
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Guinea pig
- GPC
gene engineering:
- Type: Recombinant vector construction
- Description: Vector Yellow Fever Vaccine 17D (YFV17D) expressed the Lassa virus glycoprotein precursor (LASV-GPC) (Bredenbeek et al., 2006).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Guinea pig Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: The YFV17D/LAS-GPC vaccination elicited humoral immune responses against YFV17D and LASV antigens. Neutralizing antibodies play the major role in protection against yellow fever (Bredenbeek et al., 2006).
- Efficacy: A single subcutaneous injection of the recombinant vaccine protected 13 guinea pigs against fatal Lassa Fever (Bredenbeek et al., 2006).
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| References |
Bredenbeek et al., 2006: Bredenbeek PJ, Molenkamp R, Spaan WJ, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov I, Patterson J, Carrion R, Ticer A, Brasky K, Lukashevich IS. A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins. Virology. 2006 Feb 20; 345(2); 299-304. [PubMed: 16412488].
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