• Vaccine Name: Leishmania major DNA vaccine KMP-11
• Target Pathogen: Leishmania major
• Target Disease: Cutaneous leishmaniasis
• Vaccine Ontology ID: VO_0004373
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: KMP-11 (Bhaumik et al., 2009)
• KMP-11 gene engineering:
  • Type: DNA vaccine construction
  • Description: Since this vaccine was cross-protective, the KMP-11 gene was from L. donovani (Bhaumik et al., 2009).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000230
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Lesion size of the LM infected groups immunized additionally with IL-12 showed significant reduction at 12 weeks post-infection compared to mice immunized with KMP-11 DNA alone (p < 0.05). Moreover, we examined the parasite loads in the local draining lymph nodes which showed ∼96.2% and 94% reduction in parasite burden in groups of immunized mice treated additionally with (IL-12p35 + IL-12p40) DNA or rmIL-12, respectively (p < 0.05). KMP-11 DNA immunized mice showed 69% reduction in LM-load in draining lymph node suggesting KMP-11 DNA immunization alone was partially protective against LM (Bhaumik et al., 2009).