• Vaccine Name: Herpes simplex virus DNA vaccine gBDNA encoding gB
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004369
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• UL27 from Herpes simplex virus type 1 gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expressed glycoprotein B of HSV (gBDNA) (Toka and Rouse, 2005).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005031
• Immunization Route: intranasal immunization

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: pIL-15 generated memory CD8 T cell responses that were threefold higher and mainly maintained in the spleen, but high levels of immunoglobulin A antibodies were induced and maintained long-term in the vaginal mucosa (Toka and Rouse, 2005).
• Efficacy: The enhanced immune responses ensuing from this strategy of immunization were protective upon lethal challenge with HSV-1. Five out of six mice survived after challenge (Toka and Rouse, 2005).