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Vaccine Detail
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Herpes simplex virus DNA vaccine gB-DNA encoding gB |
| Vaccine Information |
- Vaccine Name: Herpes simplex virus DNA vaccine gB-DNA encoding gB
- Target Pathogen: Herpes simplex virus type 1 and 2
- Target Disease: Herpes
- Vaccine Ontology ID: VO_0004368
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- UL27 from Herpes simplex virus type 1
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine encodes glycoprotein B (gB) (Manickan et al., 1997).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005031
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The majority of mice immunized with plasmid DNA encoding gB resisted challenge with 10 ID50 of virus (Manickan et al., 1997).
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| References |
Manickan et al., 1997: Manickan E, Kanangat S, Rouse RJ, Yu Z, Rouse BT. Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. Journal of leukocyte biology. 1997; 61(2); 125-132. [PubMed: 9021916].
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