• Vaccine Name: Herpes simplex virus DNA vaccine ∆gB-2 encoding gB
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004366
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, guinea pig
• UL27 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector V1Jns expressed the hsV-2 gB gene (McClements et al., 1996).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000328
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The DNA immunization has the capacity to elicit cell-mediated, as well as humoral immune responses. In addition, injection of mice showed that each construction induced neutralizing serum antibodies (McClements et al., 1996).
• Efficacy: Immunized and control (saline-injected) mice were challenged by i.p. injection of HSV-2 and observed daily for survival. Significant protection from death was found for each dose tested (P< 0.01 for the 30, 10, and 3 ug groups, and P = 0.027 for the 1 ug group) (McClements et al., 1996).