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Vaccine Detail
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M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs) |
| Vaccine Information |
- Vaccine Name: M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
- Target Pathogen: Mycobacterium tuberculosis
- Target Disease: Tuberculosis
- Vaccine Ontology ID: VO_0004363
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- MPT64
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 encoded MPT-64 (Morris et al., 2000).
- Detailed Gene Information: Click Here.
- MPT83
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 encoded MPT-83 (Morris et al., 2000).
- Detailed Gene Information: Click Here.
- KatG
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 encoded KatG (Morris et al., 2000).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pJW4303 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: The relative protection in the lung induced by the combination vaccine approached the BCG response in these experiments (Morris et al., 2000).
- Information about this animal model: Mouse Model for TB research
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| References |
Morris et al., 2000: Morris S, Kelley C, Howard A, Li Z, Collins F. The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine. 2000; 18(20); 2155-2163. [PubMed: 10715531].
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