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Vaccine Detail
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SIV DNA vaccine pVacc4 encoding env from mac239 |
| Vaccine Information |
- Vaccine Name: SIV DNA vaccine pVacc4 encoding env from mac239
- Target Pathogen: Simian Immunodeficiency Virus
- Target Disease: Simian AIDS
- Vaccine Ontology ID: VO_0004343
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- env
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005067
- Immunization Route: oculo-nasal route
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: After rectal challenge of vaccinated and naive animals with SHIV89.6P, all animals became infected. However a subset were protected from CD4+ T cell loss and AIDS development. Thus, nasal vaccination with SHIV-DNA plus IL-2/Ig DNA and rMVA can provide significant protection from disease progression (Bertley et al., 2004).
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| References |
Bertley et al., 2004: Bertley FM, Kozlowski PA, Wang SW, Chappelle J, Patel J, Sonuyi O, Mazzara G, Montefiori D, Carville A, Mansfield KG, Aldovini A. Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates. Journal of immunology (Baltimore, Md. : 1950). 2004; 172(6); 3745-3757. [PubMed: 15004179].
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