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Vaccine Detail

Ebola virus recombinant vector vaccine EBO7 encoding GP from SEBOV and ZEBOV
Vaccine Information
  • Vaccine Name: Ebola virus recombinant vector vaccine EBO7 encoding GP from SEBOV and ZEBOV
  • Target Pathogen: Ebola virus
  • Target Disease: Ebola hemorrhagic fever
  • Vaccine Ontology ID: VO_0004337
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Macaque
  • GP from Sudan ebolavirus gene engineering:
    • Type: Recombinant vector construction
    • Description: Vector CAdVax expressed GP from SEBOV (Pratt et al., 2010).
    • Detailed Gene Information: Click Here.
  • GP from Zaire ebolavirus gene engineering:
    • Type: Recombinant vector construction
    • Description: Vector CAdVax expressed GP from ZEBOV (Pratt et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Macaque Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Significantly, protection against SEBOV given as an aerosol challenge, which has not previously been shown, could be achieved with a boosting vaccination (Pratt et al., 2010).
References
Pratt et al., 2010: Pratt WD, Wang D, Nichols DK, Luo M, Woraratanadharm J, Dye JM, Holman DH, Dong JY. Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector. Clinical and vaccine immunology : CVI. 2010; 17(4); 572-581. [PubMed: 20181765].