|
|
Vaccine Detail
|
Ebola virus recombinant vector vaccine EBO7 encoding GP from SEBOV and ZEBOV |
| Vaccine Information |
- Vaccine Name: Ebola virus recombinant vector vaccine EBO7 encoding GP from SEBOV and ZEBOV
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004337
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- GP from Sudan ebolavirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector CAdVax expressed GP from SEBOV (Pratt et al., 2010).
- Detailed Gene Information: Click Here.
- GP from Zaire ebolavirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector CAdVax expressed GP from ZEBOV (Pratt et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Significantly, protection against SEBOV given as an aerosol challenge, which has not previously been shown, could be achieved with a boosting vaccination (Pratt et al., 2010).
|
| References |
Pratt et al., 2010: Pratt WD, Wang D, Nichols DK, Luo M, Woraratanadharm J, Dye JM, Holman DH, Dong JY. Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector. Clinical and vaccine immunology : CVI. 2010; 17(4); 572-581. [PubMed: 20181765].
|
|
